反应详情

A suspension of 2-(2-nitrophenyl)thiazolo[4,5-c]pyridine (1.170 g, 4.6 mmol), Fe powder (1.26 g, 22.8 mmol) and NH4Cl (1.97 g, 36.8 mmol) in CH3OH : H2O (4:1, 80 mL) was refluxed for 6 hrs. The mixture was filtered and the filtrate was evaporated in vacuo. The residue was poured into water. The precipitate was collected by filtration, and washed with water (20 mL×3) to afford 2-thiazolo[4,5-c]pyridin-2-yl-phenylamine as a yellow solid (0.760 g, yield: 73%).

1. temperaturewas refluxed for 6 hrs
2. filtrationThe mixture was filtered
3. customthe filtrate was evaporated in vacuo
4. additionThe residue was poured into water
5. filtrationThe precipitate was collected by filtration
6. washwashed with water (20 mL×3)