Sodium Sulfite → Sodium 2-(4-nitroanilino)ethanesulfonate

Participants

Reaction Steps

661 g (2.7 mol) of (2-bromoethyl)(4-nitrophenyl)amine (7) were partially dissolved in 3.7 L of 96% ethanol. At about 75-80° C., aqueous sodium sulfite solution (820 g, 6.5 mol of Na2SO3 in 2.4 L of water) was added. The mixture was stirred at reflux for 11 hours. The resulting mixture was filtered while boiling and the filtrate was allowed to cool. A yellow precipitate formed, which was filtered off by suction and washed with acetone. After drying, 623 g of product were isolated.

Provenance & Evidence