反应详情

661 g (2.7 mol) of (2-bromoethyl)(4-nitrophenyl)amine (7) were partially dissolved in 3.7 L of 96% ethanol. At about 75-80° C., aqueous sodium sulfite solution (820 g, 6.5 mol of Na2SO3 in 2.4 L of water) was added. The mixture was stirred at reflux for 11 hours. The resulting mixture was filtered while boiling and the filtrate was allowed to cool. A yellow precipitate formed, which was filtered off by suction and washed with acetone. After drying, 623 g of product were isolated.

1. temperatureat reflux for 11 hours
2. filtrationThe resulting mixture was filtered
3. temperatureto cool
4. customA yellow precipitate formed
5. filtrationwhich was filtered off by suction
6. washwashed with acetone
7. customAfter drying