反应详情

Methyl 4-hydroxyphenylacetate (6.00 g, 36.11 mmol) was dissolved in acetone (90 ml), and then potassium carbonate (9.98 g, 72.22 mmol) and geranyl bromide(14.34 ml, 72.22 mmol) were added thereto. After being refluxed for 4 hours, the mixture, with water added thereto, was extracted with ethyl acetate. The organic layer was washed with saturated ammonium chloride water and saturated brine successively, and dried over MgSO4. The solvent was evaporated out and the obtained residue was purified by silica gel column chromatography (5% ethyl acetate/hexane), to give methyl 2-{4-[(3,7-dimethyl-2,6-octadienyl)oxy]phenyl}acetate (10.07 g, 92%).

1. temperatureAfter being refluxed for 4 hours
2. extractionwas extracted with ethyl acetate
3. washThe organic layer was washed with saturated ammonium chloride water and saturated brine successively
4. dry with materialdried over MgSO4
5. customThe solvent was evaporated out
6. customthe obtained residue was purified by silica gel column chromatography (5% ethyl acetate/hexane)