HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxybenzenesulfonyl chloride → Tert-butyl 2-{[(4-methoxyphenyl)sulfonyl]amino}-3-methylbutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxybenzenesulfonyl chloride | HCID 7401 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | tert-butyl (2S)-2-amino-3-methylbutanoate hydrochloride | HCID 12490702 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Tert-butyl 2-{[(4-methoxyphenyl)sulfonyl]amino}-3-methylbutanoate | HCID 10783604 | — |
Reaction Steps
Valine tert-butyl ester hydrochloride is reacted with 4-methoxybenzenesulfonyl chloride in dichloromethane in the presence of triethylamine, to give tert-butyl 2-{[(4-methoxyphenyl)sulfonyl]amino}-3-methylbutanoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07348017B2 |
| Source dataset | uspto-grants-2008_03 |
| ORD ID | ord-11278647e6234e5ca65db9883609ea29 |
| Source note | uspto-grants-2008_03 |