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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1393868Generated: October 31, 2026

4-Methoxybenzenesulfonyl chloride → 1-(4-Methoxybenzene-1-sulfonyl)proline

https://huagongshe.com/reaction/1393868

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methoxybenzenesulfonyl chlorideHCID 7401—
ReactantTriethylamineHCID 8471—
ReactantL-ProlineHCID 145742—
SolventDichloromethaneHCID 6344—
Product1-(4-Methoxybenzene-1-sulfonyl)prolineHCID 2882267—

Reaction Steps

Proline is reacted with 4-methoxybenzenesulfonyl chloride in dichloromethane in the presence of triethylamine, to give 1-[(4-methoxyphenyl)sulfonyl]-2-pyrrolidinecarboxylic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07348017B2
Source datasetuspto-grants-2008_03
ORD IDord-40e9dc017ec84152b2e30f86840286f0
Source noteuspto-grants-2008_03