4-Methoxybenzenesulfonyl chloride → 1-(4-Methoxybenzene-1-sulfonyl)proline

HRID 1393868Notes

Reaction equation

HRID 1393868 reaction equation
[NH:1]1[CH2:8][CH2:7][CH2:6][C@H:2]1[C:3]([OH:5])=[O:4].[CH3:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([S:17](Cl)(=[O:19])=[O:18])=[CH:13][CH:12]=1.C(N(CC)CC)C>ClCCl>[CH3:9][O:10][C:11]1[CH:12]=[CH:13][C:14]([S:17]([N:1]2[CH2:8][CH2:7][CH2:6][CH:2]2[C:3]([OH:5])=[O:4])(=[O:19])=[O:18])=[CH:15][CH:16]=1

Participants

5

Reactant 3

HCID 74014-Methoxybenzenesulfonyl chlorideHCID 8471TriethylamineHCID 145742L-Proline

Product 1

HCID 28822671-(4-Methoxybenzene-1-sulfonyl)proline

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Proline is reacted with 4-methoxybenzenesulfonyl chloride in dichloromethane in the presence of triethylamine, to give 1-[(4-methoxyphenyl)sulfonyl]-2-pyrrolidinecarboxylic acid.

Sources & evidence

ORD record
ord-40e9dc017ec84152b2e30f86840286f0
Source dataset
uspto-grants-2008_03
Patent number
US07348017B2

Reaction notes

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