Acetic Acid → 2-Oxo-3-[1-(2-trifluoromethyl-phenyl)-cyclobutyl]-propionic acid

HRID 1393912ノート

反応式

HRID 1393912 の反応式
C([O:3][C:4](=[CH:8][C:9]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]([F:22])([F:21])[F:20])[CH2:12][CH2:11][CH2:10]1)[C:5]([OH:7])=[O:6])C.C(O)(=O)C.O>S(=O)(=O)(O)O>[O:3]=[C:4]([CH2:8][C:9]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]([F:20])([F:21])[F:22])[CH2:10][CH2:11][CH2:12]1)[C:5]([OH:7])=[O:6]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 962WaterHCID 668669652-Ethoxy-3-[1-(2-trifluoromethyl-phenyl)-cyclobutyl]-acrylic acid

生成物 1

HCID 596809512-Oxo-3-[1-(2-trifluoromethyl-phenyl)-cyclobutyl]-propionic acid収率 97.9%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

4.6 g of 2-Ethoxy-3-[1-(2-trifluoromethyl-phenyl)-cyclobutyl]-acrylic acid was stirred in 100 ml of 1M sulfuric acid and 15 ml of concentrated acetic acid overnight at 100° C. Water was added, extracted with ethyl acetate, and ethyl acetate solution was dried and concentrated by evaporation in a vacuum. The product (4.1 g) was obtained as a brown oil.

後処理

  1. customat 100° C
  2. extractionextracted with ethyl acetate, and ethyl acetate solution
  3. customwas dried
  4. concentrationconcentrated by evaporation in a vacuum

出典と根拠

ORDレコード
ord-32d7e59d04d342a5b523e3d87d879aed
出典データセット
uspto-grants-2008_03
特許番号
US07348322B2

反応ノート

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