反应详情

4.6 g of 2-Ethoxy-3-[1-(2-trifluoromethyl-phenyl)-cyclobutyl]-acrylic acid was stirred in 100 ml of 1M sulfuric acid and 15 ml of concentrated acetic acid overnight at 100° C. Water was added, extracted with ethyl acetate, and ethyl acetate solution was dried and concentrated by evaporation in a vacuum. The product (4.1 g) was obtained as a brown oil.

1. customat 100° C
2. extractionextracted with ethyl acetate, and ethyl acetate solution
3. customwas dried
4. concentrationconcentrated by evaporation in a vacuum