Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → 2-Oxo-3-[1-(2-trifluoromethyl-phenyl)-cyclobutyl]-propionic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | 2-Ethoxy-3-[1-(2-trifluoromethyl-phenyl)-cyclobutyl]-acrylic acid | HCID 66866965 | — |
| 용매 | Sulfuric Acid | HCID 1118 | — |
| 생성물 | 2-Oxo-3-[1-(2-trifluoromethyl-phenyl)-cyclobutyl]-propionic acid | HCID 59680951 | 97.9% |
반응 단계
4.6 g of 2-Ethoxy-3-[1-(2-trifluoromethyl-phenyl)-cyclobutyl]-acrylic acid was stirred in 100 ml of 1M sulfuric acid and 15 ml of concentrated acetic acid overnight at 100° C. Water was added, extracted with ethyl acetate, and ethyl acetate solution was dried and concentrated by evaporation in a vacuum. The product (4.1 g) was obtained as a brown oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07348322B2 |
| 출처 데이터셋 | uspto-grants-2008_03 |
| ORD ID | ord-32d7e59d04d342a5b523e3d87d879aed |
| 출처 메모 | uspto-grants-2008_03 |