HCID 86599745, compound → HCID 86599744, compound

HRID 1393914Notes

Reaction equation

HRID 1393914 reaction equation
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][CH2:15][N:14]([P:18]([NH:22][CH3:23])([NH:20][CH3:21])=[O:19])[C:13]1=[O:24])=O)C1C=CC=CC=1>CO.[Pd]>[NH2:11][C@H:12]1[CH2:17][CH2:16][CH2:15][N:14]([P:18]([NH:22][CH3:23])([NH:20][CH3:21])=[O:19])[C:13]1=[O:24]

Participants

4

Reactant 1

HCID 86599745HCID 86599745, compound

Product 1

HCID 86599744HCID 86599744, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Palladium black (52 mg) was added to a solution of (3S)-3-benzyloxycarbonylamino-1-bis(methylamino)phosphinyl-2-piperidone (524.1 mg, 1.4791 mmol) in methanol (5.2 mL), and the resulting mixture was stirred at room temperature for 3 hours under a hydrogen atmosphere.

Sources & evidence

ORD record
ord-1eeb1a7165f1463892f5331efd812c3c
Source dataset
uspto-grants-2008_03
Patent number
US07348318B2

Reaction notes

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