HCID 178458089, compound → HCID 178458088, compound

HRID 1393922Notes

Reaction equation

HRID 1393922 reaction equation
C(OC([NH:11][C@:12]1([PH:20]([NH:22][CH2:23][CH2:24][CH3:25])=[O:21])[CH2:17][CH2:16][CH2:15][N:14]([NH2:18])[C:13]1=[O:19])=O)C1C=CC=CC=1>CO.[Pd]>[NH2:11][C:12]1([PH:20]([NH:22][CH2:23][CH2:24][CH3:25])=[O:21])[CH2:17][CH2:16][CH2:15][N:14]([NH2:18])[C:13]1=[O:19]

Participants

4

Reactant 1

HCID 178458089HCID 178458089, compound

Product 1

HCID 178458088HCID 178458088, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Palladium black (16 mg) was added to a solution of (3S)-3-benzyloxycarbonylamino-1-amino(n-propylamino)phosphinyl-2-piperidone (161.1 g, 0.4373 mmol) in methanol (3 mL), and the resulting mixture was stirred at room temperature for 50 minutes under a hydrogen atmosphere.

Sources & evidence

ORD record
ord-c44e1675fede41c9991429b04438c544
Source dataset
uspto-grants-2008_03
Patent number
US07348318B2

Reaction notes

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