HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 1-(4-Fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | N-(3-Fluoro-4-(5-methyl-6-(2-(4-methylpiperazin-1-yl)ethoxy)pyrrolo[2,1-f][1,2,4]triazin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide | HCID 16112844 | — |
| Reactant | 1-(4-Fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid | HCID 21081527 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Product | 1-(4-Fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonyl chloride | HCID 59680956 | 100% |
Reaction Steps
To a suspension of 1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid) (Compound J of Example 1) 475 mg, 2.04 mmol), was added oxalyl chloride (388 mg, 3 mmol), followed by one drop of DMF. The resulting mixture was stirred at rt for 1 h. The mixture was then concentrated in vacuo to afford the desired compound (500 mg, 100%) as a beige solid, which was used directly in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07348325B2 |
| Source dataset | uspto-grants-2008_03 |
| ORD ID | ord-6c70b606fc9f4afe95dd260297576a66 |
| Source note | uspto-grants-2008_03 |