反应详情

To a suspension of 1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid) (Compound J of Example 1) 475 mg, 2.04 mmol), was added oxalyl chloride (388 mg, 3 mmol), followed by one drop of DMF. The resulting mixture was stirred at rt for 1 h. The mixture was then concentrated in vacuo to afford the desired compound (500 mg, 100%) as a beige solid, which was used directly in the next step without further purification.

1. concentrationThe mixture was then concentrated in vacuo