Methyl iodide → HCID 178503334, compound

HRID 1393953Notes

Reaction equation

HRID 1393953 reaction equation
[CH3:1][I:2].[CH3:3][CH:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][C:6](=[S:14])[NH:5]1>CC(C)=O>[IH:2].[CH3:3][CH:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:7]=[C:6]([S:14][CH3:1])[NH:5]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 12360758HCID 12360758, compound

Product 1

HCID 178503334HCID 178503334, compoundYield 67.9%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Methyl iodide (0.43 ml, 6.94 mmol) was added to a solution of 4-methyl-3,4-dihydro-1H-quinazoline-2-thione (410 mg, 2.30 mmol) in acetone (5 ml). The mixture was stirred for 15 min (r.t.), and the title compound (500 mg, 67%) was isolated from the reaction mixture by filtration.

Sources & evidence

ORD record
ord-8d565d8b9680445abbe8b27ed2e0f16b
Source dataset
uspto-grants-2008_03
Patent number
US07348332B2

Reaction notes

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