Trifluoroacetic acid → HCID 69309205, compound

HRID 1394048Notes

Reaction equation

HRID 1394048 reaction equation
[CH2:1]([C@H:8]([NH:26]C(=O)OC(C)(C)C)[C:9]([N:11]1[CH2:16][CH2:15][CH:14]([O:17][C:18]2[CH:23]=[CH:22][C:21]([F:24])=[C:20]([F:25])[CH:19]=2)[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>ClCCl>[CH2:1]([C@H:8]([NH2:26])[C:9]([N:11]1[CH2:12][CH2:13][CH:14]([O:17][C:18]2[CH:23]=[CH:22][C:21]([F:24])=[C:20]([F:25])[CH:19]=2)[CH2:15][CH2:16]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86760633HCID 86760633, compound

Product 1

HCID 69309205HCID 69309205, compoundYield 106.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product from Example 5, Step (a) (1.2 g) was dissolved in dichloromethane (10 ml) and trifluoroacetic acid (5 ml) was added. After 1 hr at room temperature the solution was evaporated and aqueous NaOH (2M) added. The product was extracted with ethyl acetate, the combined organic extracts dried, filtered and concentrated to give the sub-title product as an oil (1 g).

Workup

  1. customAfter 1 hr at room temperature the solution was evaporated
  2. additionaqueous NaOH (2M) added
  3. extractionThe product was extracted with ethyl acetate
  4. customthe combined organic extracts dried
  5. filtrationfiltered
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-01fa1c52a7fc4b80bc0319e2e444cb68
Source dataset
uspto-grants-2008_03
Patent number
US07348341B2

Reaction notes

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