Trifluoroacetic acid → HCID 69312083, compound

HRID 1394053Notes

Reaction equation

HRID 1394053 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][C:28]=1[Cl:29])[O:5][CH:6]1[CH2:11][CH2:10][N:9]([C:12]([C@@H:14]([NH:18]C(=O)OC(C)(C)C)[CH:15]([CH3:17])[CH3:16])=[O:13])[CH2:8][CH2:7]1.FC(F)(F)C(O)=O>ClCCl>[Cl:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][C:28]=1[Cl:29])[O:5][CH:6]1[CH2:7][CH2:8][N:9]([C:12]([C@@H:14]([NH2:18])[CH:15]([CH3:16])[CH3:17])=[O:13])[CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86760634HCID 86760634, compound

Product 1

HCID 69312083HCID 69312083, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product from Example 7, Step (a) (1.57 g) was dissolved in dichloromethane (14 ml) and trifluoroacetic acid (4 ml) was added. After 2 hours at room temperature the solution was evaporated and aqueous NaOH (2M) was added. The product was extracted with ethyl acetate, the combined organic extracts dried, filtered and concentrated to give the sub-title product as an oil (1.12 g).

Workup

  1. customAfter 2 hours at room temperature the solution was evaporated
  2. additionaqueous NaOH (2M) was added
  3. extractionThe product was extracted with ethyl acetate
  4. customthe combined organic extracts dried
  5. filtrationfiltered
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-e19f0ab12d9a4cb3a3760cad06c420cf
Source dataset
uspto-grants-2008_03
Patent number
US07348341B2

Reaction notes

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