HCID 69312134, compound → HCID 69309310, compound

HRID 1394056Notes

Reaction equation

HRID 1394056 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][C:27]=1[F:28])[O:5][CH:6]1[CH2:11][CH2:10][N:9]([CH:12]([CH3:24])[CH2:13][NH:14]C(=O)CC2C=CC=CC=2)[CH2:8][CH2:7]1>Cl>[F:1][C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][C:27]=1[F:28])[O:5][CH:6]1[CH2:7][CH2:8][N:9]([CH:12]([CH3:24])[CH2:13][NH2:14])[CH2:10][CH2:11]1

Participants

3

Reactant 1

HCID 69312134HCID 69312134, compound

Product 1

HCID 69309310HCID 69309310, compoundYield 52.5%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
60 °C

Procedure

To the product of Example 10, Step (a) (0.772 g) was added 50% conc HCl/50% MeOH (20 ml) and the reaction heated to 60° C. for 2 days. Evaporation of solvent and purification by flash silica column chromatography using 10% MeOH188.9% CH2Cl2/0.1% aq. NH3 as eluent gave the sub-title compound (0.282 g).

Workup

  1. customEvaporation of solvent and purification by flash silica column chromatography

Sources & evidence

ORD record
ord-733770a930e64d6fb026aa8456dc559e
Source dataset
uspto-grants-2008_03
Patent number
US07348341B2

Reaction notes

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