Methyl 1-benzyl-4-hydroxypiperidine-4-carboxylate → Methyl 4-hydroxypiperidine-4-carboxylate

HRID 1394089Notes

Reaction equation

HRID 1394089 reaction equation
C([N:8]1[CH2:13][CH2:12][C:11]([OH:18])([C:14]([O:16][CH3:17])=[O:15])[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[OH-].[OH-].[Pd+2]>[OH:18][C:11]1([C:14]([O:16][CH3:17])=[O:15])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

4

Reactant 1

HCID 12343427Methyl 1-benzyl-4-hydroxypiperidine-4-carboxylate

Product 1

HCID 21093366Methyl 4-hydroxypiperidine-4-carboxylate

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

Methyl 1-benzyl-4-hydroxy-4-piperidinecarboxylate in methanol was treated with Pd(OH)2 (20% on carbon, 500 mg) under a hydrogen atmosphere. The mixture was allowed to stir at room temperature for 12 hours, filtered, and the filtrate was concentrated under reduced pressure.

Workup

  1. filtrationfiltered
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-e11ebae4121d40ca90473bcc33dd8185
Source dataset
uspto-grants-2008_03
Patent number
US07348343B2

Reaction notes

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