反应详情

To a solution of 2-bromochlorobenzene (0.12 mL, 1 mmol) and 2-formylbenzeneboronic acid (0.17 g, 1.1 mmol) in toluene (9 mL) were added 2M aq. sodium carbonate (1.2 mL) followed by (Ph3P)4Pd (0.34 g, 0.3 mmol). The resulting reaction mixture was refluxed for 3 h, cooled and diluted ethyl acetate. The organic phase was washed with water, saturated aq. sodium bicarbonate, brine and dried over sodium sulfate. The filtrate was concentrated in vacuo and the residue obtained was purified by chromatography (hexane:ethyl acetate; 4:1) to yield the title product.

1. customThe resulting reaction mixture
2. temperaturewas refluxed for 3 h
3. temperaturecooled
4. washThe organic phase was washed with water, saturated aq. sodium bicarbonate, brine
5. dry with materialdried over sodium sulfate
6. concentrationThe filtrate was concentrated in vacuo
7. customthe residue obtained
8. customwas purified by chromatography (hexane:ethyl acetate; 4:1)