tert-butyl N-(2-oxoethyl)carbamate → HCID 59681805, compound

HRID 1394213Notes

Reaction equation

HRID 1394213 reaction equation
Cl.Cl.[NH2:3][C:4]1[C:5]([C:9]2[N:10]([CH2:26][CH3:27])[C:11]3[C:16]([C:17]([N:19]4[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]4)=[O:18])=[CH:15][N:14]=[CH:13][C:12]=3[N:25]=2)=[N:6][O:7][N:8]=1.O=[CH:29][CH2:30][NH:31][C:32](=[O:38])[O:33][C:34]([CH3:37])([CH3:36])[CH3:35]>ClCCCl>[C:34]([O:33][C:32](=[O:38])[NH:31][CH2:30][CH2:29][N:22]1[CH2:23][CH2:24][N:19]([C:17]([C:16]2[C:11]3[N:10]([CH2:26][CH3:27])[C:9]([C:5]4[C:4]([NH2:3])=[N:8][O:7][N:6]=4)=[N:25][C:12]=3[CH:13]=[N:14][CH:15]=2)=[O:18])[CH2:20][CH2:21]1)([CH3:37])([CH3:36])[CH3:35]

Participants

4

Reactant 2

HCID 4247255tert-butyl N-(2-oxoethyl)carbamateHCID 69159381HCID 69159381, compound

Product 1

HCID 59681805HCID 59681805, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

A mixture of the free base from Example 250, Step 3 (prepared by eluting a sample of the dihydrochloride salt through an SCX cartridge using ammonia (10%) in ethanol) and tert-butyl N-(2-oxoethyl)carbamate (0.065 g, 0.41 mmol) in 1,2-dichloroethane (5 ml) was stirred at room temperature for 20 mins. This was then treated according to the method of Example 200 to afford the title compound; MS (ES+) m/e 486 [M+H]+.

Workup

  1. customprepared
  2. washby eluting a sample of the dihydrochloride salt through an SCX cartridge
  3. additionThis was then treated

Sources & evidence

ORD record
ord-9def61cb705742f7815dcfc142aea62a
Source dataset
uspto-grants-2008_03
Patent number
US07348339B2

Reaction notes

Loading…