Hydrochloric Acid → HCID 131726812, compound

HRID 1394214Notes

Reaction equation

HRID 1394214 reaction equation
[ClH:1].C(OC(=O)[NH:8][CH2:9][CH2:10][N:11]1[CH2:16][CH2:15][N:14]([C:17]([C:19]2[C:20]3[N:27]([CH2:28][CH3:29])[C:26]([C:30]4[C:34]([NH2:35])=[N:33][O:32][N:31]=4)=[N:25][C:21]=3[CH:22]=[N:23][CH:24]=2)=[O:18])[CH2:13][CH2:12]1)(C)(C)C>CO>[ClH:1].[ClH:1].[NH2:8][CH2:9][CH2:10][N:11]1[CH2:12][CH2:13][N:14]([C:17]([C:19]2[C:20]3[N:27]([CH2:28][CH3:29])[C:26]([C:30]4[C:34]([NH2:35])=[N:33][O:32][N:31]=4)=[N:25][C:21]=3[CH:22]=[N:23][CH:24]=2)=[O:18])[CH2:15][CH2:16]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59681805HCID 59681805, compound

Product 1

HCID 131726812HCID 131726812, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Ethereal hydrogen chloride (1.0M; 1 ml) was added to a solution of the product from example 251 (0.042 g, 0.086 mmol) in methanol (2 ml) and the solution stirred at room temperature for 16 h. The solvent was evaporated and the residual solid triturated under ether (10 ml) and filtered to give the title compound as a colourless solid (0.039 g, 99%); MS (ES+) m/e 386 [M+H]+.

Workup

  1. customThe solvent was evaporated
  2. customthe residual solid triturated under ether (10 ml)
  3. filtrationfiltered

Sources & evidence

ORD record
ord-49f6b2227345425db30ce4a6d2f403fd
Source dataset
uspto-grants-2008_03
Patent number
US07348339B2

Reaction notes

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