反应详情

In order to produce the hydrochloride (Example 14), the more polar diastereomer of N-(4-dimethylamino-4-phenylcyclohexyl)-2-(2-1H-indol-3-ylacetylamino)propionamide (297 mg, 0.66 mmole) was dissolved in ethyl methyl ketone and combined with trimethylchlorosilane (125 μl, 0.99 mmole). The resulting solid was filtered out and dried. Example 14 was obtained as a colorless solid (m.p. 30-32° C.) in a yield of 200 mg (63%).

1. filtrationThe resulting solid was filtered out
2. customdried