Potassium Iodide → HCID 18538872, compound
Reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:8][C:9]1[S:13][C:12]([S:14][CH:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)=[N:11][N:10]=1.[C:21]([N:24]1[CH2:29][CH2:28][CH:27]([C:30]([N:32]([C:37]2[CH:42]=[CH:41][CH:40]=[C:39]([Cl:43])[CH:38]=2)[CH2:33][CH2:34][CH2:35]Cl)=[O:31])[CH2:26][CH2:25]1)(=[O:23])[CH3:22].C(=O)([O-])[O-].[K+].[K+].[I-].[K+].[Cl-].[Na+]>C(#N)C>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[C:21]([N:24]1[CH2:29][CH2:28][CH:27]([C:30]([N:32]([C:37]2[CH:42]=[CH:41][CH:40]=[C:39]([Cl:43])[CH:38]=2)[CH2:33][CH2:34][CH2:35][N:18]2[CH2:19][CH2:20][CH:15]([S:14][C:12]3[S:13][C:9]([CH3:8])=[N:10][N:11]=3)[CH2:16][CH2:17]2)=[O:31])[CH2:26][CH2:25]1)(=[O:23])[CH3:22]Participants
Conditions
- Temperature
- 80 °C
Procedure
4-(5-Methyl-1,3,4-thiadiazol-2-ylthio)piperidine trifluoroacetate (59 mg, 0.18 mmol) was dissolved in dry acetonitrile (1.5 mL). To the solution were added 1-acetyl-N-(3-chlorophenyl)-N-(3-chloropropyl)-4-piperidinecarboxamide (50 mg, 0.14 mmol), potassium carbonate (77 mg, 0.56 mmol) and potassium iodide (23 mg, 0.14 mmol), and the mixture was stirred at 80° C. for 5 hours. The mixture was cooled to room temperature, and to the mixture was added saturated sodium chloride solution (3 mL). The mixture was extracted three times with ethyl acetate (2 mL). The extracts were combined and concentrated under reduced pressure. The concentrate; was purified by using HPLC to give the titled compound as a colorless oily substance (32.2 mg, 28%).
Workup
- temperatureThe mixture was cooled to room temperature
- extractionThe mixture was extracted three times with ethyl acetate (2 mL)
- concentrationconcentrated under reduced pressure
- customwas purified
Sources & evidence
- ORD record
- ord-763433ea3c764cad9991361c4baef56e
- Source dataset
- uspto-grants-2008_03
- Patent number
- US07348324B2
Reaction notes
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