反应详情

温度

25 °C

Zaleplon (22.8 g) is dissolved in ethanol (230 cm3) at reflux temperature then treated with charcoal (2.3 g, 10 m/m %). The solution is stirred for 10 minutes and filtered. The charcoal is washed with hot ethanol (20 cm3). The solution is cooled to 25° C. in 6 hours and kept at this temperature for 2 hours. Crystals are filtered and washed with ethanol (30 cm3). The product is dried under vacuum at 60° C. for 8 hours to afford zaleplon form 1 (18.7 g, 82%).

1. temperatureat reflux temperature
2. filtrationfiltered
3. washThe charcoal is washed with hot ethanol (20 cm3)
4. waitkept at this temperature for 2 hours
5. filtrationCrystals are filtered
6. washwashed with ethanol (30 cm3)
7. customThe product is dried under vacuum at 60° C. for 8 hours