HCID 57436592, compound → HCID 17981885, compound

HRID 1394410Notes

Reaction equation

HRID 1394410 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:14]=[CH:13][C:12](/[CH:15]=[CH:16]/[C:17]([O:19][CH3:20])=[O:18])=[CH:11][CH:10]=2)=[CH:4][CH:3]=1>CCOC(C)=O.[Pd]>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][C:17]([O:19][CH3:20])=[O:18])=[CH:11][CH:10]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 57436592HCID 57436592, compound

Product 1

HCID 17981885HCID 17981885, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A solution of ester from step 2 in EtOAc (0.2M) containing 10% Pd/C (0.15 g/mmol) was agitated under hydrogen (50 psi, Parr apparatus) for 3 h. The mixture was filtered over Celite and the solvent evaporated to afford the title compound.

Workup

  1. filtrationThe mixture was filtered over Celite
  2. customthe solvent evaporated

Sources & evidence

ORD record
ord-bda81844e7d940a8adb8658e8e66e9f7
Source dataset
uspto-grants-2008_03
Patent number
US07348433B2

Reaction notes

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