Hydrochloric Acid → 1-Phenyl-2-chloro-2-methylpropane

HRID 1394554Notes

Reaction equation

HRID 1394554 reaction equation
[C:1]1([CH2:7][C:8](O)([CH3:10])[CH3:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:12]>>[C:1]1([CH2:7][C:8]([Cl:12])([CH3:10])[CH3:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 75312-Methyl-1-phenyl-2-propanol

Product 1

HCID 2963571-Phenyl-2-chloro-2-methylpropane

Procedure

A mixture of 5.92 g (40 mmol) of 1-phenyl-2-hydroxy-2-methylpropane and 50 mL of conc. hydrochloric acid was stirred at ice bath temperature for 1 h and at RT for 3 h. The reaction mixture was then extracted with ether. The organic layer was dried over MgSO4. Solvent removal gave 1-phenyl-2-chloro-2-methylpropane.

Workup

  1. waitat RT for 3 h
  2. extractionThe reaction mixture was then extracted with ether
  3. dry with materialThe organic layer was dried over MgSO4
  4. customSolvent removal

Sources & evidence

ORD record
ord-a865688d40234cb98460a56f568677f3
Source dataset
uspto-grants-2008_03
Patent number
US07348456B2

Reaction notes

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