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HRID1394562

反应详情

EQUATION

反应方程式

HRID 1394562 的结构方程式

REACTANTS

反应物

3
结构：CC(C)(O)C(=O)O
HCID11671

2-Hydroxyisobutyric acid

C4H8O3

结构：[H-].[Na+]
HCID24758

Sodium hydride

HNa

结构：FC(F)(F)c1ccc(Cl)nc1.FC(F)(F)c1ccnc(Cl)c1
HCID22270567

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(Oc1ccc(C(F)(F)F)cn1)C(=O)O
HCID16098342

2-Methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanoic acid

C10H10F3NO3

PROCEDURE

实验过程

The title compound was prepared following the procedure described in Reference Example 36, Step A with 1.5 extra equivalent of sodium hydride substituting lithium lactate with hydroxyisobutyric acid and 2-chloro-4-trifluoromethylpyridine 2-chloro-5-trifluoromethylpyridine. 1H NMR (500 MHz, CD3OD): δ 8.38 (br, 1H), 7.94 (dd, 1H), 6.93 (d, 1H), 1.69 (s, 6H).