Lithium Hydroxide → (S)-3-{4-[2-(3-chloro-phenyl)-5-methyl-oxazol-4-ylmethoxy]-2,6-dimethyl-phenyl}-2-ethoxy-propionic acid

HRID 1394776Notes

Reaction equation

C[O:2][C:3](=[O:32])[C@@H:4]([O:29][CH2:30][CH3:31])[CH2:5][C:6]1[C:11]([CH3:12])=[CH:10][C:9]([O:13][CH2:14][C:15]2[N:16]=[C:17]([C:21]3[CH:26]=[CH:25][CH:24]=[C:23]([Cl:27])[CH:22]=3)[O:18][C:19]=2[CH3:20])=[CH:8][C:7]=1[CH3:28].[Li+].[OH-]>>[Cl:27][C:23]1[CH:22]=[C:21]([C:17]2[O:18][C:19]([CH3:20])=[C:15]([CH2:14][O:13][C:9]3[CH:10]=[C:11]([CH3:12])[C:6]([CH2:5][C@H:4]([O:29][CH2:30][CH3:31])[C:3]([OH:32])=[O:2])=[C:7]([CH3:28])[CH:8]=3)[N:16]=2)[CH:26]=[CH:25][CH:24]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 69284039(S)-3-{4-[2-(3-chloro-phenyl)-5-methyl-oxazol-4-ylmethoxy]-2,6-dimethyl-phenyl}-2-ethoxy-propionic acid methyl ester

Product 1

HCID 69280480(S)-3-{4-[2-(3-chloro-phenyl)-5-methyl-oxazol-4-ylmethoxy]-2,6-dimethyl-phenyl}-2-ethoxy-propionic acid

Procedure

In analogy to the procedure described in example 1 g], (S)-3-{4-[2-(3-chloro-phenyl)-5-methyl-oxazol-4-ylmethoxy]-2,6-dimethyl-phenyl}-2-ethoxy-propionic acid methyl ester was treated with LiOH to obtain (S)-3-{4-[2-(3-chloro-phenyl)-5-methyl-oxazol-4-ylmethoxy]-2,6-dimethyl-phenyl}-2-ethoxy-propionic acid as colorless solid.

Sources & evidence

ORD record: ord-c5a1c0a00b5d4067b8b0ca014074d47a
Source dataset: uspto-grants-2008_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07348349B2

Reaction notes

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