Dichloromethane → tert-butyl 4-[[4-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]oxymethyl]phenyl]methyl]piperazine-1-carboxylate

HRID 139504Notes

Reaction equation

HRID 139504 reaction equation
[Br:23][CH2:24][c:25]1[cH:26][cH:27][c:28]([CH2:29][O:30][c:31]2[c:32]3[c:36]([cH:37][cH:38][cH:39]2)[C:35](=[O:40])[N:34]([CH:41]2[C:42](=[O:48])[NH:43][C:44](=[O:47])[CH2:45][CH2:46]2)[CH2:33]3)[cH:49][cH:50]1.[CH:14]([N:15]([CH2:16][CH3:17])[CH:18]([CH3:19])[CH3:20])([CH3:21])[CH3:22].[Cl:51][CH2:52][Cl:53].[N:1]1([C:7](=[O:8])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13])[CH2:2][CH2:3][NH:4][CH2:5][CH2:6]1>>[N:1]1([C:7](=[O:8])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13])[CH2:2][CH2:3][N:4]([CH2:24][c:25]2[cH:26][cH:27][c:28]([CH2:29][O:30][c:31]3[c:32]4[c:36]([cH:37][cH:38][cH:39]3)[C:35](=[O:40])[N:34]([CH:41]3[C:42](=[O:48])[NH:43][C:44](=[O:47])[CH2:45][CH2:46]3)[CH2:33]4)[cH:49][cH:50]2)[CH2:5][CH2:6]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 81531DiisopropylethylamineHCID 143452tert-Butyl piperazine-1-carboxylateHCID 583891963-[7-[[4-(bromomethyl)phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione

Product 1

HCID 53353411tert-butyl 4-[[4-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]oxymethyl]phenyl]methyl]piperazine-1-carboxylate

Sources & evidence

ORD record
ord-4f4c7f02b6734b8fb259525e7adb51f9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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