4-Quinolinecarboxylic acid → Quinoline-4-carbonyl chloride hydrochloride

HRID 1395047Notes

Reaction equation

[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]([OH:13])=O)=[CH:3][CH:2]=1.S(Cl)([Cl:16])=O>>[ClH:16].[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]([Cl:16])=[O:13])=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 102434-Quinolinecarboxylic acid

HCID 24386Thionyl Chloride

Product 1

HCID 12373997Quinoline-4-carbonyl chloride hydrochlorideYield 78%

Procedure

2-[4'-(5"-nitrofuryl-2")-1,3-butadienyl]quinoline-4-carboxylic acid chloride hydrochloride was prepared as described in Example 1 from 2-[4-(5"-nitrofuryl-2")-1,3-butadienyl]quinoline-4-carboxylic acid and thionyl chloride with the yield of 78%, m.p. 230°-232° C. (with decomposition).

Sources & evidence

ORD record: ord-1c6ffbfba08d4293ad89afe78044feb5
Source dataset: uspto-grants-1980_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04201784

Reaction notes

Loading…