HCID 20335297, compound → HCID 19020936, compound

HRID 1395135Notes

Reaction equation

HRID 1395135 reaction equation
[C:1]([C:3](=[C:13]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:4]([O:6][CH2:7][CH2:8][O:9]C(=O)C)=[O:5])#[N:2]>Cl.CO>[C:1]([C:3](=[C:13]([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)[C:4]([O:6][CH2:7][CH2:8][OH:9])=[O:5])#[N:2]

Participants

4

Reactant 1

HCID 20335297HCID 20335297, compound

Product 1

HCID 19020936HCID 19020936, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidCatalystHCID 887MethanolSolvent

Procedure

A charge of 800 ml. of methanol, 335 g. (1 mole) of 2-acetoxyethyl 2-cyano-3,3-diphenylacrylate and 10 drops of concentrated hydrochloric acid was heated at 65° C. for 18 hours. Evaporation of the solvent left 235 g. (80%) of the intermediate compound as an amber, viscous oil.

Workup

  1. additionA charge of 800 ml
  2. customEvaporation of the solvent
  3. waitleft 235 g

Sources & evidence

ORD record
ord-b5eb77aa905c4e0eb2baaa62b2e28b18
Source dataset
uspto-grants-1980_05
Patent number
US04202834

Reaction notes

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