Trichloroacetyl chloride → HCID 20340652, compound

HRID 1395152Notes

Reaction equation

HRID 1395152 reaction equation
[F:1][C:2]([F:23])([F:22])[CH2:3][NH:4][C:5]1[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[CH:15][C:6]=1[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8].[Cl:24][C:25]([Cl:30])([Cl:29])[C:26](Cl)=[O:27]>>[F:1][C:2]([F:22])([F:23])[CH2:3][N:4]([C:5]1[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[CH:15][C:6]=1[C:7]([C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)=[O:8])[C:26](=[O:27])[C:25]([Cl:30])([Cl:29])[Cl:24]

Participants

3

Reactant 2

HCID 6420Trichloroacetyl chlorideHCID 20340656HCID 20340656, compound

Product 1

HCID 20340652HCID 20340652, compound

Procedure

A mixture of 3.24 g of 2-(2,2,2-trifluoroethylamino)-5-nitrobenzophenone and 15 ml. of trichloroacetyl chloride was heated at 100° C. (bath temperature) for 5 hours. The volatiles were removed under reduced pressure. The residue was chromatographed on silica gel using benzene as an eluent to give 2-[N-(2,2,2-trifluoroethyl)trichloroacetamido]-5-nitrobenzophenone as an yellow oil.

Workup

  1. customThe volatiles were removed under reduced pressure
  2. customThe residue was chromatographed on silica gel

Sources & evidence

ORD record
ord-26a12168b5534146984bde4a536849e7
Source dataset
uspto-grants-1980_05
Patent number
US04202895

Reaction notes

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