Methylamine → HCID 85916620, compound

HRID 1395227Notes

Reaction equation

HRID 1395227 reaction equation
Cl[C:2]1[C:7]2[CH:8]=[N:9][C:10]3[N:14]([CH2:15][CH3:16])[N:13]=[CH:12][C:11]=3[C:6]=2[N:5]2[N:17]=[CH:18][C:19]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[C:4]2[N:3]=1.[CH3:25][NH2:26]>>[CH2:15]([N:14]1[C:10]2[N:9]=[CH:8][C:7]3[C:2]([NH:26][CH3:25])=[N:3][C:4]4[N:5]([N:17]=[CH:18][C:19]=4[C:20]([O:22][CH2:23][CH3:24])=[O:21])[C:6]=3[C:11]=2[CH:12]=[N:13]1)[CH3:16]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 85916602HCID 85916602, compound

Product 1

HCID 85916620HCID 85916620, compound

Procedure

3.5 g of 5-chloro-8-ethyl-8H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidine-3-carboxylic acid, ethyl ester (0.01 mol) and 3.5 g of methylamine are heated in 50 ml of alcohol in an autoclave for 10 hours at 100°. The solvent is removed in vacuo and the residue treated with water, filtered off and recrystallized from butyl alcohol, yield 2.9 g (86%); m.p. 321°-322°.

Workup

  1. customThe solvent is removed in vacuo
  2. additionthe residue treated with water
  3. filtrationfiltered off
  4. customrecrystallized from butyl alcohol, yield 2.9 g (86%)

Sources & evidence

ORD record
ord-49af2137492943aa822b66b7ca791752
Source dataset
uspto-grants-1980_05
Patent number
US04202899

Reaction notes

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