5-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamine → 1-Nitro-2-(2-propynylamino)-2-{2-[(5-dimethylaminomethyl-2-furyl)methylthio]ethylamino}ethylene

HRID 1395377Notes

Reaction equation

HRID 1395377 reaction equation
CS[C:3]([NH:8][CH2:9][C:10]#[CH:11])=[CH:4][N+:5]([O-:7])=[O:6].[CH3:12][N:13]([CH2:15][C:16]1[O:20][C:19]([CH2:21][S:22][CH2:23][CH2:24][NH2:25])=[CH:18][CH:17]=1)[CH3:14]>>[N+:5]([CH:4]=[C:3]([NH:8][CH2:9][C:10]#[CH:11])[NH:25][CH2:24][CH2:23][S:22][CH2:21][C:19]1[O:20][C:16]([CH2:15][N:13]([CH3:14])[CH3:12])=[CH:17][CH:18]=1)([O-:7])=[O:6]

Participants

3

Reactant 2

HCID 1622035-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamineHCID 71401969N-[1-(Methylsulfanyl)-2-nitroethenyl]prop-2-yn-1-amine

Product 1

HCID 1734131-Nitro-2-(2-propynylamino)-2-{2-[(5-dimethylaminomethyl-2-furyl)methylthio]ethylamino}ethylene

Procedure

A solution of the product of Step A is reacted with about an equimolar amount of 2-[(5-dimethylaminomethyl-2-furyl)methylthio]ethylamine to give, after workup and chromatography as in Example 1, the title compound.

Workup

  1. customto give

Sources & evidence

ORD record
ord-6e1a511ec2244b6a9ff82b25ab018e30
Source dataset
uspto-grants-1980_05
Patent number
US04203909

Reaction notes

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