5-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamine → N-Cyano-N'-(2-propyn-1-yl)-N"-{2-[(5-dimethylaminomethyl-2-furyl)methylthio]ethyl}guanidine

HRID 1395379Notes

Reaction equation

HRID 1395379 reaction equation
[C:1]([NH:3][C:4](=[N:7][CH2:8][C:9]#[CH:10])SC)#[N:2].[CH3:11][N:12]([CH2:14][C:15]1[O:19][C:18]([CH2:20][S:21][CH2:22][CH2:23][NH2:24])=[CH:17][CH:16]=1)[CH3:13]>>[C:1]([NH:3][C:4]([NH:7][CH2:8][C:9]#[CH:10])=[N:24][CH2:23][CH2:22][S:21][CH2:20][C:18]1[O:19][C:15]([CH2:14][N:12]([CH3:13])[CH3:11])=[CH:16][CH:17]=1)#[N:2]

Participants

3

Reactant 2

HCID 1622035-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamineHCID 2805748Carbamimidothioic acid, N-cyano-N'-2-propynyl-, methyl ester

Product 1

HCID 136088352N-Cyano-N'-(2-propyn-1-yl)-N"-{2-[(5-dimethylaminomethyl-2-furyl)methylthio]ethyl}guanidine

Procedure

The product of Step A is reacted with about an equimolar amount of 2-[(5-dimethylaminomethyl-2-furyl)methylthio]ethylamine in a non-reactive solvent to give, after workup and chromatography as in Example 3, the title product.

Workup

  1. customto give

Sources & evidence

ORD record
ord-94d2b60317074c9191de57358d65310e
Source dataset
uspto-grants-1980_05
Patent number
US04203909

Reaction notes

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