5-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamine → HCID 86736989, compound

HRID 1395389Notes

Reaction equation

HRID 1395389 reaction equation
C[N:2]([CH2:4][C:5]1OC(CSCCN)=C[CH:6]=1)C.C(C=C(OC)OC)#N.[C:23]([CH:25]=[C:26](OC)[NH:27][CH2:28][CH2:29][S:30][CH2:31][C:32]1[O:33][C:34]([CH2:37][N:38]([CH3:40])[CH3:39])=[CH:35][CH:36]=1)#[N:24].C(N)C#C>>[C:23]([CH:25]=[C:26]([NH:2][CH2:4][C:5]#[CH:6])[NH:27][CH2:28][CH2:29][S:30][CH2:31][C:32]1[O:33][C:34]([CH2:37][N:38]([CH3:40])[CH3:39])=[CH:35][CH:36]=1)#[N:24]

Participants

5

Reactant 4

HCID 1622035-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamineHCID 239041PropargylamineHCID 226227003,3-Dimethoxyprop-2-enenitrileHCID 70591953HCID 70591953, compound

Product 1

HCID 86736989HCID 86736989, compound

Procedure

Alternatively, when 2-[(5-dimethylaminomethyl-2-furyl)methylthio]ethylamine is reacted with 1-cyano-2,2-bis(methoxy)ethylene and the resultant 1-cyano-2-methoxy-2-{2-[(5-dimethylaminomethyl-2-furyl)methylthio]ethylamino}ethylene is reacted with propargylamine according to the general procedure of Example 1, the title product is produced.

Sources & evidence

ORD record
ord-ba40fd493d854866aca1b2b5b47fa7c6
Source dataset
uspto-grants-1980_05
Patent number
US04203909

Reaction notes

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