Hydrochloric Acid → HCID 20339415, compound

HRID 1395461Notes

Reaction equation

HRID 1395461 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][CH2:8][N:9]2[CH2:27][CH2:26][N:12]3[C:13]4[C:18]([NH:19][C:20](=[O:21])[CH:11]3[CH2:10]2)=[CH:17][C:16]([C:22]([F:25])([F:24])[F:23])=[CH:15][CH:14]=4)=[CH:3][CH:2]=1.C(O)C.Cl>[Pt]=O.O>[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][CH2:8][N:9]2[CH2:27][CH2:26][N:12]3[C:13]4[C:18]([NH:19][C:20](=[O:21])[CH:11]3[CH2:10]2)=[CH:17][C:16]([C:22]([F:25])([F:23])[F:24])=[CH:15][CH:14]=4)[CH2:3][CH2:2]1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 20339428HCID 20339428, compound

Product 1

HCID 20339415HCID 20339415, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 962WaterSolvent

Procedure

A mixture of 5 g. (0.014 mole) of 2,3,4,4a-tetrahydro-3-[2-(4-pyridinyl)ethyl]-8-trifluoromethyl-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one, 60 ml. of ethanol, 120 ml. of water, 12 ml. of concentrated hydrochloric acid and 1 g. of platinum oxide catalyst was hydrogenated in a Parr apparatus for 2 hours. The catalyst was filtered and the solvents removed. The residue was crystallized two times from methanol to yield 42 g. of the title compound as the dihydrochloride salt, m.p. 279°-282° C.

Workup

  1. additionA mixture of 5 g
  2. filtrationThe catalyst was filtered
  3. customthe solvents removed
  4. customThe residue was crystallized two times from methanol
  5. customto yield 42 g

Sources & evidence

ORD record
ord-dd11d3fc6d20491798efa3a477a4c063
Source dataset
uspto-grants-1980_05
Patent number
US04203987

Reaction notes

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