Acetic Anhydride → N-[6-(Dimethylamino)-2-pyridinyl]acetamide

HRID 1395538Notes

Reaction equation

HRID 1395538 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N:8]([CH3:10])[CH3:9])[N:3]=1.[C:11](OC(=O)C)(=[O:13])[CH3:12]>C1C=CC=CC=1>[CH3:9][N:8]([CH3:10])[C:4]1[N:3]=[C:2]([NH:1][C:11](=[O:13])[CH3:12])[CH:7]=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 22287845N,N-Dimethyl-2,6-pyridinediamine

Product 1

HCID 20339658N-[6-(Dimethylamino)-2-pyridinyl]acetamide

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

Acetylation of 2-amino-6-dimethylaminopyridine from Part A with acetic anhydride in benzene for 2 hours at reflux gives a quantative yield of the title compound. Melting point is 118°-119°.

Sources & evidence

ORD record
ord-b32c3fbbd5f0466e87b1ec0c620caa01
Source dataset
uspto-grants-1980_05
Patent number
US04203988

Reaction notes

Loading…