HCID 20339444, compound → HCID 20339636, compound

HRID 1395539Notes

Reaction equation

HRID 1395539 reaction equation
C([O:4][CH2:5][CH2:6][NH:7][C:8]([N:10]([CH2:19][CH2:20][N:21]([CH3:23])[CH3:22])[C:11]1[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13]([CH3:18])[N:12]=1)=[O:9])(=[O:3])C>C(O)C>[OH2:3].[OH2:3].[OH:4][CH2:5][CH2:6][NH:7][C:8]([N:10]([CH2:19][CH2:20][N:21]([CH3:23])[CH3:22])[C:11]1[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13]([CH3:18])[N:12]=1)=[O:9]

Participants

3

Reactant 1

HCID 20339444HCID 20339444, compound

Product 1

HCID 20339636HCID 20339636, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of N-(2-acetoxyethyl)-N'-(2-dimethylamino ethyl)-N'-(4,6-dimethyl-2-pyridyl)urea (11.5 g, 0.034 mole) in 1:1 ethanol-aqueous ammonia (300 ml.) is allowed to overnight at room temperature. The solvent is then removed under vacuum and the residue is crystallized from acetonitrile. The yield of crude product is 7.30 g, m.p. 173-176. Recrystallization from acetonitrile gives pure product melitng at 177°-179° C.

Workup

  1. customThe solvent is then removed under vacuum
  2. customthe residue is crystallized from acetonitrile
  3. customRecrystallization from acetonitrile
  4. customgives pure product melitng at 177°-179° C.

Sources & evidence

ORD record
ord-7abfbbf7417641468be8e7e00980fa95
Source dataset
uspto-grants-1980_05
Patent number
US04203988

Reaction notes

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