HCID 20339647, compound → HCID 20339538, compound

HRID 1395545Notes

Reaction equation

HRID 1395545 reaction equation
[CH3:1][N:2]([CH3:17])[C:3]([N:5]([CH2:14][C:15]#[N:16])[C:6]1[CH:11]=[C:10]([CH3:12])[CH:9]=[C:8]([CH3:13])[N:7]=1)=[O:4].[H][H]>C(OCC)(=O)C.[Pt]=O>[CH3:17][N:2]([CH3:1])[C:3]([N:5]([CH2:14][CH2:15][NH2:16])[C:6]1[CH:11]=[C:10]([CH3:12])[CH:9]=[C:8]([CH3:13])[N:7]=1)=[O:4]

Participants

5

Reactant 2

HCID 20339647HCID 20339647, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20339538HCID 20339538, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 8857Ethyl AcetateSolvent

Procedure

A solution of N,N-dimethyl-N'-(cyanomethyl)-N'-(4,6-dimethyl-2-pyridyl)urea from Part B (5.3 g., 0.023 mole) in ethyl acetate (100 ml.) containing platinum oxide (0.8 g.) is hydrogenated in a Parr apparatus at 50 psi of hydrogen until the required amount is taken up (12 hours). The catalyst is filtered off and the solvent removed under vacuum to give 4.6 g. of oily product.

Workup

  1. custom(12 hours)
  2. filtrationThe catalyst is filtered off
  3. customthe solvent removed under vacuum
  4. customto give 4.6 g

Sources & evidence

ORD record
ord-c2a5514542eb40988ecf7fc5e3aac697
Source dataset
uspto-grants-1980_05
Patent number
US04203988

Reaction notes

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