反应详情

2-(2-diisopropylaminoethylamino)-4-methoxypyridine-N-oxide (4.3 g., 15 mmole) dissolved in glacial acetic acid (32 ml.) is refluxed with iron powder (8.2 g.) for three hours. The reaction mixture is filtered to remove insoluble salts and then the solvent evaporated. The residue is dissolved in methanol, treated with excess potassium hydroxide pellets and filtered to remove more insoluble salts. The concentrate solution is dissolved in chloroform, washed with water, dried over sodium sulfate, filtered through a pad of charcoal and evaporated to give oily product.

1. filtrationThe reaction mixture is filtered
2. customto remove insoluble salts
3. customthe solvent evaporated
4. dissolutionThe residue is dissolved in methanol
5. additiontreated with excess potassium hydroxide pellets
6. filtrationfiltered
7. customto remove more insoluble salts
8. dissolutionThe concentrate solution is dissolved in chloroform
9. washwashed with water
10. dry with materialdried over sodium sulfate
11. filtrationfiltered through a pad of charcoal
12. customevaporated
13. customto give oily product