HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Phenoxybenzyl alcohol → m-Phenoxybenzyl 4-(2-fluorophenyl)-2-isopropyl-3-butenoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Phenoxybenzyl alcohol | HCID 26295 | — |
| Reactant | (2-Fluorophenyl)acetaldehyde | HCID 17770161 | — |
| Reactant | 4-(2-Fluorophenyl)-2-isopropyl-3-butenoic acid | HCID 53709105 | — |
| Reactant | Ethyl 4-(2-fluorophenyl)-2-isopropyl-3-butenoate | HCID 54550563 | — |
| Product | m-Phenoxybenzyl 4-(2-fluorophenyl)-2-isopropyl-3-butenoate | HCID 54247680 | — |
Reaction Steps
2-Fluorophenylacetaldehyde is converted into ethyl 4-(2-fluorophenyl)-2-isopropyl-3-butenoate and hydrolyzed to the acid using the procedure of Example 9. The acid, 4-(2-fluorophenyl)-2-isopropyl-3-butenoic acid, is reacted, via the acid chloride, with m-phenoxybenzyl alcohol to yield m-phenoxybenzyl 4-(2-fluorophenyl)-2-isopropyl-3-butenoate, MS m/e 404.3 (M+). 2-Fluorophenylacetaldehyde is prepared from o-fluoro-β-methoxystyrene via the dimethylacetal using the procedure of Winterfeldt, Berichte 96(12), 3349 (1963).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04204071 |
| Source dataset | uspto-grants-1980_05 |
| ORD ID | ord-c17b03b58e274b7f8bdb08cdf1b9b5eb |
| Source note | uspto-grants-1980_05 |