3-(Dimethylamino)-1-propanol → N,N1-Dimethyl-S-(3-dimethylaminopropyl)isothiourea

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Reaction Steps

A mixture of 3-dimethylaminopropanol (10.3 g), N,N1 -dimethylthiourea (10.4 g) and aqueous hydrobromic acid (48%, 60 ml) was boiled under reflux for 18 hours and evaporated to dryness. The residue was recrystallised from ethanol to give the dihydrobromide of the title compound m.p. 173°-174°. (Found: C, 27.4; H, 6.0; N, 12.0; S, 9.1; Br, 45.3; C8H19N3S.2HBr, requires: C, 27.4; H, 6.0; N, 12.0; S, 9.1; Br. 45.5%.)

Provenance & Evidence