反应详情

To a suspension of 10 g. of 2-(2-methyl-3-trifluoromethylanilino) nicotinic acid and 160 ml. of glacial acetic acid, add 9 ml. of 30% hydrogen peroxide solution at room temperature. Warm the reaction mixture on a steam bath for one hour and add an additional 5 ml. of 30% hydrogen peroxide. Heat the resulting mixture for three hours on a steam bath, dilute with water and filter. After recrystallization from acetic acid, the product, 5-hydroxy-2-(2-methyl-3-trifluoromethylanilino) nicotinic acid melts at 305°-308° (dec.)

1. additionTo a suspension of 10 g
2. customat room temperature
3. temperatureWarm the reaction mixture on a steam bath for one hour
4. additionadd an additional 5 ml
5. temperatureHeat the resulting mixture for three hours on a steam bath
6. filtrationfilter
7. customAfter recrystallization from acetic acid