4-[15-(Trifluoromethyl)pentadecylamino]benzoic acid → 4-[15-(Trifluoromethyl)pentadecylamino]benzoyl chloride hydrochloride

HRID 1395711Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1395711
[F:1][C:2]([F:29])([F:28])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:23](O)=[O:24])=[CH:21][CH:20]=1.C(COC)OC.C(Cl)[Cl:37]>>[ClH:37].[F:1][C:2]([F:29])([F:28])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([Cl:37])=[O:24])=[CH:21][CH:20]=1

Komponenten

3

Edukt 2

HCID 128316104-[15-(Trifluoromethyl)pentadecylamino]benzoic acidHCID 86634710Dimethoxyethane methylene chloride

Produkt 1

HCID 205493174-[15-(Trifluoromethyl)pentadecylamino]benzoyl chloride hydrochloride

Versuchsvorschrift

A cold solution of 25 g. of 4-[15-(trifluoromethyl)pentadecylamino]benzoic acid in 500 ml. dimethoxyethane-methylene chloride (4:1) is prepared and dry hydrochloric acid is bubbled through the solution until no more precipitate forms. The solution is treated with 25 ml. thionyl chloride and refluxed until all of the precipitate has dissolved. The solvents are evaporated to yield 4-[15-(trifluoromethyl)pentadecylamino]benzoyl chloride hydrochloride as an orange, semi-crystalline mass.

Aufarbeitung

  1. customdry hydrochloric acid is bubbled through the solution until no more precipitate forms
  2. additionThe solution is treated with 25 ml
  3. temperaturethionyl chloride and refluxed until all of the precipitate
  4. dissolutionhas dissolved
  5. customThe solvents are evaporated

Quellen und Nachweise

ORD-Eintrag
ord-bfb426177f05433998272a53dc95cc46
Quelldatensatz
uspto-grants-1980_05
Patentnummer
US04205085

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