反应详情

the mixture of 26 mg of ethyl 2-(10,11-dihydro dibenzo[b,f]thiepin-3-yl)-propionate, 1 ml of ethanol, 200 mg of potassium hydroxide and 1 ml of water was stirred at room temperature for 1 hour. The solvent was distilled off to obtain the residue, which was acidified with hydrochloric acid and the resulting mixture was extracted with ethyl acetate. The extract was washed with saturated sodium chloride solution and dried over anhydrous sodium sulfate. The solvent was distilled off to obtain 24 ml of 2-(10,11-dihydro dibenzo[b,f]thiepin-3-yl)-propionic acid as pale yellow oil.

1. distillationThe solvent was distilled off
2. customto obtain the residue, which
3. extractionthe resulting mixture was extracted with ethyl acetate
4. washThe extract was washed with saturated sodium chloride solution
5. dry with materialdried over anhydrous sodium sulfate
6. distillationThe solvent was distilled off