Sodium Hydroxide → HCID 131711773, compound

HRID 1395777Notes

Reaction equation

HRID 1395777 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([NH:9][CH:10]1[C:29](=[O:30])[N:12]2[C:13]([C:26]([OH:28])=[O:27])=[C:14]([CH2:17][S:18][C:19]3[S:20][C:21]([CH2:24][NH2:25])=[N:22][N:23]=3)[CH2:15][S:16][C@H:11]12)=[O:8].[OH-].[Na+:32].O.[Na+].O[CH2:36][S:37]([O-:40])(=[O:39])=[O:38]>O>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([NH:9][CH:10]1[C:29](=[O:30])[N:12]2[C:13]([C:26]([O-:28])=[O:27])=[C:14]([CH2:17][S:18][C:19]3[S:20][C:21]([CH2:24][NH:25][CH2:36][S:37]([OH:40])(=[O:39])=[O:38])=[N:22][N:23]=3)[CH2:15][S:16][C@H:11]12)=[O:8].[Na+:32].[Na+:32].[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([NH:9][CH:10]1[C:29](=[O:30])[N:12]2[C:13]([C:26]([O-:28])=[O:27])=[C:14]([CH2:17][S:18][C:19]3[S:20][C:21]([CH2:24][NH:25][CH2:36][S:37]([OH:40])(=[O:39])=[O:38])=[N:22][N:23]=3)[CH2:15][S:16][C@H:11]12)=[O:8]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 23713651HCID 23713651, compoundHCID 70584193HCID 70584193, compound

Product 1

HCID 131711773HCID 131711773, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a suspension of 7-{2-(2-thienyl)acetamido}-3-(5-aminomethyl-1,3,4-thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acid (1.39 g.) in water (27 ml.) was added 1 N aqueous sodium hydroxide solution (3 ml.) to dissolve. After hydroxymethanesulfonic acid sodium salt hydrate (456 mg.) was added to the resultant solution, the solution was stirred at room temperature for 4.5 hours, was lyophilized to give di-sodium 7-(2-thienyl)acetamido-3-(5-sulfomethylaminomethyl-1,3,4-thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylate m.p. 112° to 120° C. (dec.).

Workup

  1. dissolutionto dissolve

Sources & evidence

ORD record
ord-420a81e9745e4875a3c389800a44a0f6
Source dataset
uspto-grants-1980_05
Patent number
US04205166

Reaction notes

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