Sodium Hydroxide → HCID 131711773, compound

Participants

Reaction Steps

To a suspension of 7-{2-(2-thienyl)acetamido}-3-(5-aminomethyl-1,3,4-thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acid (1.39 g.) in water (27 ml.) was added 1 N aqueous sodium hydroxide solution (3 ml.) to dissolve. After hydroxymethanesulfonic acid sodium salt hydrate (456 mg.) was added to the resultant solution, the solution was stirred at room temperature for 4.5 hours, was lyophilized to give di-sodium 7-(2-thienyl)acetamido-3-(5-sulfomethylaminomethyl-1,3,4-thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylate m.p. 112° to 120° C. (dec.).

Provenance & Evidence