Hydrochloric Acid → HCID 178479204, compound

HRID 1395782Notes

Reaction equation

HRID 1395782 reaction equation
C([NH:4][CH2:5][CH2:6][C:7]1[S:11][C:10]([SH:12])=[N:9][N:8]=1)(=O)C.[ClH:13]>O1CCOCC1>[ClH:13].[NH2:4][CH2:5][CH2:6][C:7]1[S:11][C:10]([SH:12])=[N:9][N:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178474711HCID 178474711, compound

Product 1

HCID 178479204HCID 178479204, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Thus obtained 5-(2-acetamidoethyl)-1,3,4-thiadiazole-2-thiol f(0.86 g) was dissolved in a mixture of 6 N hydrochloric acid (9 ml) and dioxane (5 ml) and the solution was heated to reflux for 2.5 hours. The solvent was distilled off and the residue was washed with ethanol to give 5-(2-aminoethyl)-1,3,4-thiadiazole-2-thiol hydrochloride (700 mg). m.p. 218° to 220° C.

Workup

  1. temperaturethe solution was heated
  2. temperatureto reflux for 2.5 hours
  3. distillationThe solvent was distilled off
  4. washthe residue was washed with ethanol

Sources & evidence

ORD record
ord-852af6a3c5a54645bf7dcd2edc1c063d
Source dataset
uspto-grants-1980_05
Patent number
US04205166

Reaction notes

Loading…