HRID1395812

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)N(C(=O)OC(C)(C)C)[N+](=O)[O-])C(C)C

HCID178501376

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)N[N+](=O)[O-])C(C)C.Cl

HCID178501377

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID176

Acetic Acid

C2H4O2

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

30.9 g of t-butoxycarbonylnitroarginylvalyltyrosine methyl ester is dissolved in 177 ml of acetic acid. To this solution is added 88.5 ml of 6 N hydrochloric acid in dioxane. The reaction is allowed to stand for five minutes and the solvent is removed under vacuum. The residue is triturated with ethyl ether. The resultant precipitate is filtered, washed with ethyl ether and dried in a vacuum oven at 55° C. to afford nitroarginylvalyltyrosine methyl ester hydrochloride.

WORKUP

后处理

customthe solvent is removed under vacuum
customThe residue is triturated with ethyl ether
filtrationThe resultant precipitate is filtered
washwashed with ethyl ether
customdried in a vacuum oven at 55° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-52b7b15ba7a8458c93963d1ed57909ba
来源数据集: uspto-grants-1980_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04204991
来源说明: uspto-grants-1980_05

反应 SMILES

[CH3:1][O:2][C:3](=[O:42])[C@H:4]([CH2:34][C:35]1[CH:40]=[CH:39][C:38]([OH:41])=[CH:37][CH:36]=1)[NH:5][C:6](=[O:33])[C@H:7]([CH:30]([CH3:32])[CH3:31])[NH:8][C:9](=[O:29])[C@H:10]([CH2:22][CH2:23][CH2:24][NH:25][C:26](=[NH:28])[NH2:27])[N:11](C(OC(C)(C)C)=O)[N+:12]([O-:14])=[O:13].[ClH:43]>C(O)(=O)C.O1CCOCC1>[ClH:43].[CH3:1][O:2][C:3](=[O:42])[C@H:4]([CH2:34][C:35]1[CH:40]=[CH:39][C:38]([OH:41])=[CH:37][CH:36]=1)[NH:5][C:6](=[O:33])[C@H:7]([CH:30]([CH3:32])[CH3:31])[NH:8][C:9](=[O:29])[C@H:10]([CH2:22][CH2:23][CH2:24][NH:25][C:26](=[NH:27])[NH2:28])[NH:11][N+:12]([O-:14])=[O:13]